AUTHOR(S) / АУТОР(И): Marijana Živković 
, Srđan Tufegdžić , Neda Đorđević
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DOI: https://doi.org/10.46793/SBT26.867Z
ABSTRACT / САЖЕТАК:
Steroidal semicarbazones (SCs) and ethyl carbazates (ECs) were evaluated for drug-likeness, ADME-related properties, and lipophilicity using multiple in silico tools and experimental shake-flask measurements. All compounds complied with Lipinski’s criteria and showed acceptable predicted absorption and distribution profiles. However, calculated log P values varied markedly among models (up to ~1.5 units). Experimental data confirmed lower lipophilicity of SCs and revealed class-dependent agreement between predicted and measured values, with iLOGP best describing SCs and XLOGP3 ECs, highlighting the need for combined computational and experimental assessment.
KEYWORDS / КЉУЧНЕ РЕЧИ:
Lipinski’s Rule of Five (Ro5), UV−Vis spectroscopy, oral bioavailability, in silico ADME, Shake-flask log P
ACKNOWLEDGEMENT / ПРОЈЕКАТ:
The research presented in this article was financially supported by the Ministry for Science, Technological Development and Innovation of the Republic of Serbia (Grants no. 451-03-136/2025-03/200026, and 451-03-136/2025-03/200017).
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