AUTHOR(S) / AUTOR(I): Ana Kesić 
, Andrija Gigić , Jovana Bogojeski , Dragana Stevanović , Jovana Bugarinović
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DOI: https://doi.org/10.46793/SBT26.785K
ABSTRACT / SAŽETAK:
The interactions of a copper(II) complex and a natural extract from Salvia pratensis root with human serum albumin (HSA) were studied using fluorescence spectroscopy, focusing on their synergistic effects. Binding studies in the presence and absence of site markers, ibuprofen and eosin Y, assessed binding affinity and potential sites. The copper(II) complex showed moderate interaction with HSA, while the extract had stronger binding. The combined system exhibited enhanced, marker-independent binding, indicating a synergistic effect. These findings suggest the extract influences the interaction between the copper complex and HSA, affecting its transport and biodistribution.
KEYWORDS / KLJUČNE REČI:
copper(II) complex, human serum albumin, synergistic effect, binding interactions, Salvia pratensis
ACKNOWLEDGEMENT / PROJEKAT:
This research is funded by the Ministry of Education and Ministry of Science, Technological Development and Innovation, Republic of Serbia, Grants: No. 451-03-136/2025-03/200378 and 451-03-136/2025-03.
REFERENCES / LITERATURA:
- Palermo, G., Spinello, A., Saha, A., & Magistrato, A. (2021). Frontiers of metal-coordinating drug design. Expert Opinion on Drug Discovery, Volume (16), 497–511. Available: https://doi.org/10.1080/17460441.2021.1851188.
- Sharmin S., Faisal A., Sayeed ur R., Tarique S., Mohammad T. (2021). Studying the interaction of drug/ligand with serum albumin, Journal of Molecular Liquids, Volume (336): 116200. Available: https://doi.org/10.1016/j.molliq.2021.116200
- Ji, P., Wang, P., Chen, H., Xu, Y., Ge, J., Tian, Z., & Yan, Z. (2023). Potential of Copper and Copper Compounds for Anticancer Applications. Pharmaceuticals, Volume (16): 234. Available: https://doi.org/10.3390/ph16020234
- Mohammad F. R. F., Mokhles M. Abd-Elzaher, Rafeek A. A., Ammar A. L. (2007). On the medicinal chemistry of ferrocene, Applied Organometallic Chemistry, Volume (21): 613-625. Available: https://doi.org/10.1002/aoc.1202
- Sharma B., Kumar V. (2021) Has Ferrocene Really Delivered Its Role in Accentuating the Bioactivity of Organic Scaffolds? J. Med. Chem, Volume (64), 16865−16921. Available: https://doi.org/10.1021/acs.jmedchem.1c00390
- Hillard E., Vessières A., Thouin L., Jaouen G., Amatore C., (2006) Ferrocene-Mediated Proton-Coupled Electron Transfer in a Series of Ferrocifen-Type Breast-Cancer Drug Candidates, Angew. Chem. Int. Ed. Volume (45) 285-290. Available: https://doi.org/10.1002/anie.200502925
- Nikola S., Danijela M., Uroš G., Sanja Lj. M., Jelena K. S., Nevena M., Daria M. M., Luigi D’E., Vladimir M. (2022). Meadow sage (Salvia pratensis L.): A neglected sage species with valuable phenolic compounds and biological potential, Industrial Crops and Products, Volume (189): 115841. Available: https://doi.org/10.1016/j.indcrop.2022.115841
- Malihe Z. E., Lars E., Mona A., Maryam B., Amir Sh. S., Mohammad R. (2020). New Journal of Chemistry. Volume (44), 20101-20114. Available: https://doi.org/10.1039/D0NJ03552A
- Xiao X., Longzhu B., Lu R., Zhenyan Y., Dingce Y., Chun-Jiang W., Huailong T. (2022). Synthesis of Bioactive Fluoropyrrolidines via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides, Chemical Science. Volume (13): 1398. Available: https://doi.org/10.1039/D1SC04595D