AUTHOR(S) / AUTOR(I): Nevena Jeremic 
, Jovana Novakovic , Vladimir Jakovljevic
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DOI: https://doi.org/10.46793/SBT26.921J
ABSTRACT / SAŽETAK:
This study aimed to compare the cardioprotective effects of pantoprazole and lansoprazole with ischemic preconditioning in isolated rat hearts subjected to ischemia–reperfusion. Both proton pump inhibitors improved left ventricular contractility, with pantoprazole showing the most pronounced effect, while also affecting heart rate and coronary flow. These findings suggest that PPIs, particularly pantoprazole, may serve as effective pharmacological preconditioning agents, enhancing myocardial recovery after ischemic injury.
KEYWORDS / KLJUČNE REČI:
benzimidazole-derived proton pump inhibitors, pharmacological preconditioning, isolated rat heart, experimental study
ACKNOWLEDGEMENT / PROJEKAT:
The research presented in this article is part of doctoral dissertation and financially supported by Grant nº 175043 from the Ministry of Science and Technical Development of the Republic of Serbia.
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