2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (690-693)
АУТОР(И) / AUTHOR(S): Edina Avdović, Dušica Simijonović, Žiko Milanović, Sandra Jovičić Milić, Sunčica Roca, Dražen Vikić-Topić
Е-АДРЕСА / E-MAIL: edina.avdovic@pmf.kg.ac.rs
DOI: 10.46793/ICCBI23.690A
САЖЕТАК / ABSTRACT:
The chromeno and pyrimidine classes compounds include a variety of hybrid molecules displaying diverse biological actions. Although they have been examined for many years, these compounds are still of interest due to their facile chemical transformations. The presence of chromeno and pyrimidine structural motifs in many drugs, prompted us to investigate the antioxidant features of compounds 5-(7-bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl) pyrimidine-2,4,6(1H,3H,5H)-tri-one (CP-1) and 8,9- ihydroxy-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione (CP-2). In this paper, we investigated in vitro antioxidant properties of selected chromeno-pyrimidine derivatives. The percentage activity of the tested compounds CP-1 and CP-2, as well as the quercetin standard, NDGA, against the DPPH radical in concentrations of 25 M, 50 M and 100 M was tested. Compound CP-2 was found to have an exceptional efficacy of 92% at a concentration of 25 μM. In addition, the IC50 value confirms a high antiradical power against DPPH radicals for the compound CP-2 (IC50 = 3.5μM) and a moderate activity for the compound CP-1 (IC50 = 55.4 μM).
КЉУЧНЕ РЕЧИ / KEYWORDS:
Chromeno-pyrimidine derivatives, Antioxidant activity assay, DPPH radical
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