2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (523-526)
АУТОР(И) / AUTHOR(S): Milica Međedović, Dejan Lazić, Milan Vraneš, Ghodrat Mahmoudi, Biljana Petrović, Ana Rilak Simović
Е-АДРЕСА / E-MAIL: milica.medjedovic@pmf.kg.ac.rs
DOI: 10.46793/ICCBI23.523M
САЖЕТАК / ABSTRACT:
In a group of transition metal complexes that scientists have synthesized to find a good replacement for cisplatin, ruthenium complexes, with various good properties, occupy a very important place. In this group, ruthenium polypyridyl complexes showed promising properties and became leading candidates for use as anticancer agents. In this study, we have synthesized a new ruthenium (II) polypyridyl complex of general formula [Ru(L)(N-N)Cl]Cl, where L is 2,2’:6’,2’’-terpyridine with the additional functional group in the 4’-position: 2-thienly and N-N=bpy (2,2’-bypiridine). The kinetics of the substitution reactions of the studied complex with important biomolecules, the nitrogen-containing ligand 5’-GMP and the S-containing ligand L-Cys, were monitored. The kinetic results showed a faster substitution of the labile aqua ligand with a nitrogen-containing ligand, than a sulfur-containing one.
КЉУЧНЕ РЕЧИ / KEYWORDS:
ruthenium(II), polypyridyl, kinetics, 5’-GMP, L-Cys
ЛИТЕРАТУРА / REFERENCES:
- E. Antonarakis, A. Emadi, Ruthenium-based chemotherapeutics: are they ready for prime time?, Cancer Chemotherapy and Pharmacology, 66 (2010) 1.
- A. Rilak Simović, R. Masnikosa, I. Bratsos, E. Alessio, Chemistry and reactivity of ruthenium(II) complexes: DNA/protein binding mode and anticancer activity are related to the complex structure, Coordination Chemistry Reviews, 398 (2019) 113011.
- M. Međedović, A. Rilak Simović, D. Ćoćić, L. Senft, S. Matić, D. Todorović, S. Popović, D. Baskić, B. Petrović., New ruthenium(II) complexes with quinone diimine and substituted bipyridine as inert ligands: synthesis, characterization, mechanism of action, DNA/HSA binding affinity and cytotoxic activity, Dalton Transactions, 52 (2023) 1323–1344.