2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (249-252)
АУТОР(И) / AUTHOR(S): M. Kosović Perutović, Z. Leka, M. Bigović, J. Mišurović, V. Medojević
Е-АДРЕСА / E-MAIL: mkosovic@ucg.ac.me
DOI: 10.46793/ICCBI23.249KP
САЖЕТАК / ABSTRACT:
As a continuation of our research in the field of synthesis and characterization of dithiocarbamate (DTC), we are developing mechanochemical protocols for the synthesis of new compounds with potential biological activity. Optimizing the methods of obtaining desired compounds is of special importance for a completely eco-friendly science, and one of the prospective strategies is mechanochemistry, recognized as a green, sustainable synthesis method. Herein we present the mechanochemical reactions of homopiperazine and CS2. The aim was to obtain homopiperazine dithiocarbamate derivative through mechanochemical synthesis. The optimization of the process was carried out through mechanochemical grinding in the planetary ball-mill using zirconium oxide grinding media (jars and balls), under various reaction conditions. The selected reactions were conducted using a one-pot method. Chemical and spectral characterization revealed that the product was obtained in the form of a dimer with a good yield. Water and NaHCO3 were generated as by-products. Homopiperazine-1,4-bis-carbodithioate was synthesized for the first time in a ball-mill under mechanochemical and solvent-free conditions. This protocol is promising and thus constitutes an appealing alternative
both in academic research and in practical processes, being simple to perform, cheap, scalable, and occurring under mild conditions.
КЉУЧНЕ РЕЧИ / KEYWORDS:
mechanochemistry, dithiocarbamates, homopiperazine, green synthesis
ЛИТЕРАТУРА / REFERENCES:
- L.Kaul, R. Suss, A. Zannettino, K. Richter., The revival of dithiocarbamates: from pesticides to innovative medical treatments, iScience, 24(2)(2021)102092
- S. Singh, J. Goo, V. Gajulapati, T.S. Chang, K. Lee, Y. Choi., Recent Advances in Anticancer Chemotherapeutics Based upon Azepine Scaffold, Anti-Cancer Agents in Medicinal Chemistry16(2016)539–557
- A. M. C.Villegas, M. Pérez-Redondo, M. L.Cardoso, A. Toscano, R. Cea-Olivares.,
Organotin(IV) azepane dithiocarbamates: Synthesis and characterization of the first organotin(IV) complexes with seven-membered cyclic dithiocarbamate, Phosphorus, Sulfur, and Silicon and the Related Elements, 159(2020)498-506J. - V.Uivarosi, M. Badea, V. Aldea, L.Chirigiu, R.Olar., Thermal and spectral studies of palladium(II) and platinum(IV) complexes with dithiocarbamate derivatives, J Therm Anal Calorim, 111 (2013) 1177-1182
- E. Garand, T. Wende, D. J. Goebbert, R.Bergmann, G. Meijer, D. M. Neumark, K. R. Asmis., Infrared Spectroscopy of Hydrated Bicarbonate Anion Clusters: HCO3-(H2O)1-10, JACS, 132(2010) 849-856