7th International Congress of Cardionephrology KARNEF (2025) [pp. 82-84]
AUTHOR(S) / АУТОР(И): Zorana Vasiljevic 
, Predrag Mitrovic, Dubravka Rajic, Natasa Zlatic
Download Full Pdf 
DOI: 10.46793/KARNEF25.058V
ABSTRACT / САЖЕТАК:
Coronary artery disease (CAD) and chronic kidney disease (CKD) may reciprocally influence each other and increased risk of many complications, especially ischemic and hemorrhagic events, which complicates the treatment and prognosis of these patients (pts). The pts with both diseases heart failure is present in 43% pts and acute myocardial (AMI) in 15% pts; the equivalent proportion in pts with CAD without kidney disease were 18.5% and 6.4% respectively (1). Not only the pts with CKD in advanced stage 4 or 5 are at high risk of CAD morbidity and mortality but, also the patients with early stage of CKD and without clinical manifestation of vascular disease (2,3). The co-existence of two diseases are strongly interrelated, and explanations could be in the same risk factors responsible for both diseases progression. The prevention of risk factors is key and possible for a better prognosis and treatment options for these pts. Traditional and mutual risk factors of CAD and CKD are age, hypertension, diabetes mellitus, dyslipidemia, tobacco use, obesity, family history and male gender. Some of these factors, as high blood pressure, glucose, lipid levels, tobacco use can and should be aggressively modified.
A common and very important findings in progression of three risk factors for CKD – hypertension, diabetes and dyslipidemia, is microalbuminuria, which is an essential predictor of identifying those patients at risk of kidney disease risk progression. National Kidney Foundation underlies the importance of early identification and treatment of CKD and its associated comorbid conditions, including cardiovascular disease (4,5).
KEYWORDS / КЉУЧНЕ РЕЧИ:
Coronary artery disease (CAD), chronic kidney disease (CKD), hypertension, diabetes melitus
REFERENCES / ЛИТЕРАТУРА:
- Centers for Disease Control and Prevention. National Center for Health Statistic. “Leading causes of death: deaths Final data for 2013, Table 10. Available at: http://www.cdc.gov/nchs/fastats/ leading-causes-of-death.htm. Accessed on:September 4, 2015
- Perk J, De Backer G, Gohlke H et al. European Association for Cardiovascular prevention and rehabilitation (EACPR). Eur Heart J 2012;33 (17):1635-701
- Briasoulis A, Bakris GL. Chronic kidney disease as a coronary artery disease risk equivalent. Curr Cardiol Rep 2013;15(3);340
- National Kidney Foundation. Am J Kidney dis 2002;39 (2suppl 1):51-5266
- Klausen K, Borch-Johnsen K, Feldt-Rasmussen B et al. Very low level of microalbuminuria are associated with increased risk for coronary artery disease and death independetely of renal function, hypertension and diabetes. Circulation 2004;110:32-5
- Thomas MC, Cooper ME, Zimmet P. Changes epidemiology of type 2 diabetes mellitus and associated chronic kidney disease. Nat Rev Nephrol. 2016;12:73-78
- A Eid Hoda, Moazen E, Ethussini M, mShaman H, Hassa A et al.The influence of Smoking on renal Functions among Apparently Healthy Smokers. Journal of Multidisciplinary Healthcare 2022;15. 2969-2978
- Fu Y-C, Xu Z-L, Zhao M-Y et al.The association between smoking and renal function in the people over 20 years old. Front Med 2022;9:870278
- Levey AS, Eckardt KU, Tsukamoto Y et al. Definition and classification of chronic kidney disease: A position statement from Kidney disease: improving Global Outcomes (KDIGO). Kidney int. 2005;67:2089-100
- KDIGO 2020 Clinical Practice Guidelines for Diabetes management in chronic kidney disease. Kidney int.2020;98 (4S):S1-S115