2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023 (483-486)
АУТОР(И) / AUTHOR(S): Anđela A. Franich, Marija D. Živković, Snežana Rajković
Е-АДРЕСА / E-MAIL: andjela.franich@pmf.kg.ac.rs
DOI: 10.46793/ICCBI23.483F
САЖЕТАК / ABSTRACT:
In order to investigate the nature of binding drugs to HSA interaction of mononuclear [Pt(5,6-epoxy-1,10-phen)Cl2] and [Pt(mal)(5,6-epoxy-1,10-phen)] complexes with HSA were followed by fluorescence emission and UV-Vis spectroscopy. To determine the preferred site of the complex binding to the HSA competitive experiments with site markers eosin Y and ibuprofen were performed. Obtained results showed that the examined complexes bind to HSA and primary interaction is at site II.
КЉУЧНЕ РЕЧИ / KEYWORDS:
Platinum(II) complexes, HSA, Eosin Y, Ibuprofen
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