1st International Conference on Chemo and BioInformatics, ICCBIKG 2021, (328-331)
AUTHOR(S) / AUTOR(I): Biljana Šmit, Asija Halilagić, Enisa Selimović, Jelena S. Katanić Stanković, Nikola Srećković, Tanja Soldatović
E-ADRESS / E-ADRESA: biljana.smit@uni.kg.ac.rs, jkatanic@kg.ac.rs, tsoldatovic@np.ac.rs, eselimovic@np.ac.rs, asija.halilagic@gmail.com, nikola.sreckovic@pmf.kg.ac.rs
DOI: 10.46793/ICCBI21.328S
ABSTRACT / SAŽETAK:
New dinuclear Zn(II)-L-Cu(II) complexes with different bridging ligands were synthesized. Interactions of these complexes with biologically important nucleophiles, 5′-GMP, 5′-IMP and GSH, were investigated by Uv-Vis spectrofotometric method. The distances between the metal ions lead to less reactivity of both centers due to reduced electronic communication between them and an increasing of electron density on the metal centers itself. Both complexes showed moderate antimicrobial activity against most of the tested bacterial and fungal strains.
KEY WORDS / KLJUČNE REČI:
heteronuclear complexes, Zn(II), Cu(II), biomolecules, bridging ligands, Uv-Vis spectroscopy
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