CYCLOOXYGENASE-2 AS „IN SILICO“ TARGET OF PHENOLIC HYDRAZONE- TYPE DERIVATIVES

1st International Conference on Chemo and BioInformatics, ICCBIKG  2021, (324-327)

AUTHOR(S) / AUTOR(I): Jovica Branković, Vesna M. Milovanović, Vladimir P. Petrović

E-ADRESS / E-ADRESA: jovica.brankovic@pmf.kg.ac.rs, vesna.milovanovic@pmf.kg.ac.rs, vladimir.petrovic@pmf.kg.ac.rs

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DOI: 10.46793/ICCBI21.324B

ABSTRACT / SAŽETAK:

In the present work, a series of phenolic hydrazone analogs were investigated in silico for their potential inhibitory activity toward COX-2. These examinations were based on the capability of hydrazone-based compounds to interact with numerous enzymes, as well as on their versatile biological features and therapeutical applications. COX-2 was selected due to its involvement in the inflammation and carcinogenesis processes. Regarding this, COX-2 represents a valid target for the development of compounds that could block the formation of harmful inflammation mediators.

KEY WORDS / KLJUČNE REČI:

hydrazones, molecular docking, COX-2

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