1st International Conference on Chemo and BioInformatics, ICCBIKG 2021, (324-327)
AUTHOR(S) / AUTOR(I): Jovica Branković, Vesna M. Milovanović, Vladimir P. Petrović
E-ADRESS / E-ADRESA: firstname.lastname@example.org, email@example.com, firstname.lastname@example.org
ABSTRACT / SAŽETAK:
In the present work, a series of phenolic hydrazone analogs were investigated in silico for their potential inhibitory activity toward COX-2. These examinations were based on the capability of hydrazone-based compounds to interact with numerous enzymes, as well as on their versatile biological features and therapeutical applications. COX-2 was selected due to its involvement in the inflammation and carcinogenesis processes. Regarding this, COX-2 represents a valid target for the development of compounds that could block the formation of harmful inflammation mediators.
KEY WORDS / KLJUČNE REČI:
hydrazones, molecular docking, COX-2
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