ELECTROPHILIC ORGANOSELENIUM COMPOUNDS AND SARS-COV-2: PRO-OXIDANT ACTIVITY AS A MORE PROMISING WAY TOWARDS THE DRUGGABILITY

1st International Conference on Chemo and BioInformatics, ICCBIKG  2021, (20-25)

AUTHOR(S) / AUTOR(I): Claudio Santi, Luca Sancineto, Francesca Mangiavacchi,Cecilia Scimmi, Sougat Misra

E-ADRESS / E-ADRESA: claudio.santi@unipg.it

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DOI: 10.46793/ICCBI21.020S

ABSTRACT / SAŽETAK:

Ebselent has been recently reported as the most efficient hinibitors of Sars-Cov-2 main protease (Mpro) thought the electrophilic covalent pro-oxidation of the reactive Cysteine 145. According to similar evidences in literature we can propose a general mechanism to explore a novel and promising application of mild organoselenium centered electrophiles in medicinal chemistry. New insights in the field of covalent and non-covalent inhibition of Mpro as well as the antiviral SARS-Cov2 activity of novel organoselenium compounds will be here discussed

KEY WORDS / KLJUČNE REČI:

Selenium, Covid-19, SARS-Cov2, electrophiles

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