АУТОР(И): Marko Antonijević, Dušica Simijonović, Ana Kesić, Edina Avdović, Zoran Marković
Е-АДРЕСА:
DOI: 10.46793/SBT26.423A
САЖЕТАК:
Kumarini su široko rasprostranjena grupa jedinjenja. Poseduju širok spektar fizioloških dejstava, od antifungalnog, preko antikoagulativnog do antikancerogenog, pa su zbog toga pronašli primenu u lečenju različitih bolesti. U ovom radu ispitivana je sposobnost (E)-N‘-1-(2,4-diokso-2H-hromen-3(4H)-ilidene)etil)-4-hidroksi-3-metoksibenzohidrazida da inaktivira reaktivne kiseoni;ne vrste. Analiza dobijenih rezultata pokazala je da SET-PT (Single Electron Transfer Followed By Proton Transfer) mehanizam nije operativan. Sa druge strane, termodinamički parametri koji opisuju HAT (Hydrogen Atom Transfer) i prvi korak SPLET (Sequential Proton Loss-Electron Transfer) mehanizma ukazuju da će oba mehanizma biti operativni. Antiradikalski kapacitet ispitivanog jedinjenja sa radikalima opada u sledećem nizu: •OH> •OCH3> •OC(CH3)3> •OOH> •OOCH3> •OOCH2CH3.
КЉУЧНЕ РЕЧИ:
Antiradikalska aktivnost, DFT, Termodinamički pristup
ЛИТЕРАТУРА:
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