AUTHOR(S) / АУТОР(И): Neda Đorđević, Vladana Petković, Otilija Keta, Nevena Todorović Vukotić, Ivana Perić, Marijana Živković, Snežana B. Pajović
DOI: 10.46793/SBT30.56NDJ
ABSTRACT / САЖЕТАК:
The wine industry advances winemaking techniques to improve wine quality, sensory attributes, and potential health benefits. This study investigates the in vitro cytotoxic effects of Muscat Hamburg red wine enriched with melatonin during vinification. The biological activity was assessed using colorectal cancer (HT-29) and pancreatic cancer (PANC-1) cell lines. Results indicate that the melatonin-enriched wine exhibits cytotoxicity against both cell lines, with a stronger effect on PANC-1 compared to control wine, while both wines had similar effects on HT-29 cells. Further research is needed to elucidate the underlying mechanisms of action in different cancer cell lines.
KEYWORDS / КЉУЧНЕ РЕЧИ:
melatonin treatment, vinification, cytotoxic activity, HT-29, PANC-1
ACKNOWLEDGEMENT / ПРОЈЕКАТ:
The research presented in this article was financially supported by the Ministry for Science, Technological Development and Innovation of the Republic of Serbia (Grants no. 451-03-136/2025-03/200017 and 451-03-66/2024- 03/200026).
REFERENCES / ЛИТЕРАТУРА:
- Baenas N., García-Viguera C., Domínguez-Perles R., Medina S. (2023). Winery By-Products as Sources of Bioactive Tryptophan, Serotonin, and Melatonin: Contributions to the Antioxidant Power. Foods. 12:1–15. doi: 10.3390/foods12081571.
- Cordente A.G., Schmidt S., Beltran G., Torija M.J., Curtin C.D. (2019). Harnessing yeast metabolism of aromatic amino acids for fermented beverage bioflavouring and bioproduction. Appl Microbiol Biotechnol. 103:4325–4336. doi: 10.1007/s00253-019-09840-w.
- Đorđević N., Todorović Vukotić N., Keta O., Petković V., Pajović S. (2024). The impact of melatonin treatment during the vinification of Moldova wine on its cytotoxic effects. Publshed in Twelfth International Conference of Radiation, Natural Sciences, Medicine, Engineering, Technology and ecology, pp 48. Herceg Novi, Montenegro. doi: 10.21175/rad.abstr.book.2024.14.5.
- Eremia S.A.V., Albu C., Radu G.L., Alecu A., Brinduse E. (2023). The Influence of Melatonin Treatment in the Vinification of Feteasca Neeagra and Cabernet Sauvignon Wines on the Profile of Polyphenolic Compounds and Antioxidant Activity. Antioxidants. 12. doi: 10.3390/antiox12061214.
- Hornedo-Ortega R., Cerezo A.B., Troncoso A.M., Garcia-Parrilla M.C., Mas A. (2016) Melatonin and other tryptophan metabolites produced by yeasts: Implications in cardiovascular and neurodegenerative diseases. Front Microbiol. 6:1–7. doi: 10.3389/fmicb.2015.01565.
- Marhuenda J., Villaño D., Arcusa R., Zafrilla P. (2021). Melatonin in wine and beer: Beneficial effects. Molecules. 26(2):343. doi: 10.3390/molecules26020343.
- Zhang Y.S., Du G., Gao Y.T., Wang L.W., Meng D., Li B.J., Brennan C., Wang M.Y., Zhao H., Wang S.Y., Guan W.Q. (2019). The effect of carbonic maceration during winemaking on the color, aroma and sensory properties of ‘Muscat Hamburg’ wine. Molecules. 24(17):1–13. doi: 10.3390/molecules24173120.