DOES THE SYNERGY OF BIOTECHNOLOGICAL AND MEDICAL APPROACHES SOLVE THE CHALLENGE OF HEAT STRESS IN DAIRY COWS? AN EXAMPLE OF INSULIN RESISTANCE AND METABOLIC-HORMONAL IMBALANCE

3rd International Symposium On Biotechnology (2025),  [pp. 7-16]

AUTHOR(S) / АУТОР(И): Marko Cincović, Mira Majkić, Radojica Đoković, Miloš Ži. Petrović, Jovan Spasojević, Sandra Nikolić, Aleksandar Čukić

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DOI: 10.46793/SBT30.02MC

ABSTRACT / САЖЕТАК:

Heat stress (HS) significantly impacts dairy cow productivity and
welfare, primarily by inducing metabolic and hormonal imbalances, particularly
insulin resistance. By examining the underlying mechanisms of HS-induced
insulin resistance and its downstream consequences, we evaluate the efficacy of
biotechnological strategies like genetic selection and rumen microbiome
manipulation, alongside medical approaches such as nutritional supplementation
and hormonal therapies in addressing this complex challenge. This review
highlights the importance of a holistic approach, combining advanced
biotechnologies with targeted veterinary interventions to develop effective
strategies for improving dairy cow resilience to HS and ensuring sustainable milk
production in a changing climate.

KEYWORDS / КЉУЧНЕ РЕЧИ:

heat stress, cow, metabolite, insulin resistance, welfare

REFERENCES / ЛИТЕРАТУРА:

  • Aggarwal A., Morrow J.D. (2019). Role of the hypothalamus in the pathophysiology of heatstroke. Comprehensive Physiology, 9, 1617-1646.
  • Aguilar-Valles A., Hook G., Luheshi G., Clarke I.J. (2015). The role of the hypothalamic-pituitary-adrenal axis in the anorexia of inflammation. Journal of Neuroendocrinology, 27, 751-760.
  • Allen M.S., Robinson P.H., Givens D.I., Wilde D.R. (2005). Predicting energy content of feeds. Journal of Dairy Science, 88, 1921-1940.
  • Baumgard L.H., Collier R.J., Rhoads R.P. (2012). Regulation of energy metabolism during heat stress. Annual Review of Animal Biosciences, 1, 311-337.
  • Baumgard L.H., Rhoads R.P. (2013). Effects of heat stress on postabsorptive metabolism and energetics. Annual Review of Animal Biosciences, 1, 311- 337.
  • Berman, A. (2006). Extending the potential of evaporative cooling for heat- stressed dairy cattle. Journal of Dairy Science, 89, 3482-3490.
  • Bernabucci U., Basiricò L., Morera P., Ronchi B., Nardone A., Lacetera N. (2010). Effect of heat stress in dairy cattle: Metabolic, hormonal and immune changes. Livestock Science, 132, 1-18.
  • Bernabucci U., Ronchi B., Basiricò L., Morera P., Di Nardo A., Lacetera N. (2010a). Metabolic and hormonal acclimation to heat stress in ruminants. Animal, 4(07), 1167-1183.
  • Blond B., Majkić M., Spasojević J., Hristov S., Radinović M., Nikolić S., Anđušić Lj., Čukić A., Došenović Marinković M., Delić Vujanović B., Obradović N., Cincović M. (2024). Influence of Heat Stress on Body Surface Temperature and Blood Metabolic, Endocrine, and Inflammatory Parameters and Their Correlation in Cows. Metabolites, 14, 104.
  • Cincović M., Majkić M., Spasojević J., Hristov S., Stanković B., Nakov D., Nikolić S., Stanojević J. (2023). Heat stress of dairy cows in Serbia. Acta Agriculturae Serbica, 28, 107‒125.
  • Collier R.J., Zimbelman R.G., VanBaale M.J., Marsh L., Rhoads R.P. (2008). Genes affecting resistance to environmental stress in dairy cattle. Journal of Dairy Science, 91, 662-673.
  • Cook N.B., Nordlund K.V., Oetzel G.R. (2004). Environmental influences on claw horn lesions associated with laminitis and subacute ruminal acidosis in dairy cows. Journal of Dairy Science, 87, E36-E46.
  • Čukić A., Rakonjac S., Djoković R., Cincović M., Bogosavljević-Bošković S., Petrović M., Savić Ž., Anđušić LJ., Andjelić, B. (2023). Influence of heat stress on body temperatures measured by infrared thermography, blood metabolic parameters and its correlation in sheep. Metabolites, 13, 957.
  • Dado R.G., Allen M.S. (1993). Continuous culture of rumen microorganisms: effect of temperature on fermentation. Journal of Animal Science, 71, 1582- 1591.
  • Deng Y., Gao M., Li J., Zhang S., Li Q. (2021). Effect of heat stress on gastrointestinal function in livestock: a review. Journal of Animal Science and Biotechnology, 12, 1-12.
  • Derbré F., Mélèse F., Culioli J.M., Allaire G. (2012). Insulin resistance and lipogenic liver diseases: New insight into the pathophysiology of metabolic disorders in dairy cows. Veterinary Journal, 192, 141-148.
  • Gaughran S.J., O’Brien B., Pierce K.M., Boland T.M. (2020). Effect of heat stress and mitigation strategies on feed intake, growth, and performance of growing beef cattle: a review. Animal, 14, s270-s280.
  • Guan L.L., Li R.W., Steele M.A., McAllister T.A. (2017). Metagenomic analysis reveals changes in rumen microbial composition and function in response to heat stress. Frontiers in Microbiology, 8, 1633.
  • Guo Z., Gao S., Ouyang J., Ma L., Bu D. (2021). Impacts of heat stress-induced oxidative stress on the milk protein biosynthesis of dairy cows. Animals, 11, 726.
  • Halachmi I., Guarino M., Bewley J., Pastell M. (2019). Smart animal agriculture: application of real-time sensors to improve animal well-being and production. Annual review of animal biosciences, 7, 403-425.
  • Hall M.B. (2005). Challenges to meet diet specifications for dairy cattle during heat stress. Journal of Animal Science, 83, E9-E18.
  • Hayirli A. (2006). The role of chromium in animal nutrition. Veterinary Clinics of North America: Food Animal Practice, 22, 431-450.
  • Mangan J.L. (1988). Nutritional effects of tannins in animal feeds. Nutrition Research Reviews, 1, 209-231.
  • Mao S.Y., W ang J.K., Zhu W Y. . (2015). Application of gut probiotics in monogastric animal feeding. Journal of Animal Science and Biotechnology, 6, 25.
  • Monteiro A.P., Favoreto M.G., Wiltbank M.C., Vieira-Neto A. (2016). Heat stress and epigenetic modifications in bovine oocytes and embryos. Theriogenology, 86, 1-10.
  • Morales-de la Cruz G.R., Rueda-Puente E.O., Garcia-Muro A., Figueroa- Rodriguez F.I., Rojo R. (2022). Effect of thermal stress on the production and quality of forage crops. Agronomy, 12, 1442.
  • Ozgul O., Seyrek-Intas K., Oktenli C., Intas D. (2018). The role of inflammatory cytokines in insulin resistance and type 2 diabetes. Journal of Diabetes Research, 1720521.
  • Pearce S.C., Logan C.B., Sherwood L., Aluthge N.D., Perry V.E., et al. (2013). The effects of heat stress on the gut integrity and immune status of broiler chickens. Journal of Thermal Biology, 38, 279-284.
  • Rhoads R.P., Kim J.W., Leiva H.A., Dahl G.E., Baumgard L.H. (2016). Heat- stress-induced insulin resistance and metabolic adjustments in lactating dairy cows. Physiology & Behavior, 163, 290-298.
  • Rhoads R.P., Kim J.W., Leury B.J., Baumgard L.H. (2010). Heat-stress and lactating dairy cattle: Metabolic, endocrine and immune responses. Journal of Dairy Science, 92, 3101-3121.
  • Russell J.B., O’Connor J.D., Fox D.G., Van Soest P.J., Sniffen C.J. (1992). A net carbohydrate and protein system for evaluating cattle diets: I. Ruminal fermentation. Journal of Animal Science, 70, 3551-3561.
  • Sreekumar D., Sejian V. (2024). Cow comfort, behavior and welfare with specific reference to dairy cattle: A review. Ger. J. Vet. Res, 4, 160-175.
  • Sivakumar A.V.N., Singh R., Chandrasekaran D., Kumar H., Gupta R.S., Varshney V.P. (2010). Oxidative stress and antioxidant status during heat stress in cattle. Biological Rhythm Research, 41, 565-571.
  • Taub D.R. (2010). Effects of rising atmospheric CO2 on plants. Nature Education Knowledge, 1, 31.
  • Van Soest P.J. (1994). Nutritional ecology of the ruminant (2nd ed.). Comstock Publishing Associates.
  • West J.W. (2003). Effects of heat-stress on production in dairy cattle. Journal of Dairy Science, 86, 2131-2144.
  • Wheelock J.B., Rhoads R.P., VanBaale M.J., Sanders S.R., Baumgard L.H. (2010). Effects of heat stress on energetic metabolism in lactating Holstein cows. Journal of dairy science, 93, 644-655.