1st International Conference on Chemo and BioInformatics, ICCBIKG 2021, (363-366)
AUTHOR(S) / АУТОР(И): Emina Mrkalić, Marina Ćendić Serafinović, Ratomir Jelić, Stefan Stojanović, Miroslav Sovrlić
E-ADRESS / Е-АДРЕСА: email@example.com, firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, email@example.com
ABSTRACT / САЖЕТАК:
Serum albumin is the major soluble protein in the circulatory system of humans. The metabolism of drugs, their distribution, free concentration, and efficacy depend on the drug-serum albumin interaction . Accordingly, it is important to study the interactions of drugs with serum albumin, which determines the pharmacology and pharmacodynamics of drugs. Quercetin (QUE), a natural polyphenol widely distributed in many plant foods, such as fruits, vegetables, nuts, seeds, grains, and tea , bind to serum albumin . Tigecycline (TGC), is a tetracycline antibiotic widely used in the treatment of bacterial infections . This study aimed to investigate the binding properties of TGC to HSA in the presence of QUE, under physiological conditions, by fluorescence spectroscopy.
KEY WORDS / КЉУЧНЕ РЕЧИ:
human serum albumin, interactions, tigecycline
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