INFLUENCE OF QUERCETIN ON THE BINDING OF TIGECYCLINE TO HUMAN SERUM ALBUMIN

AUTHOR(S) / АУТОР(И): Emina Mrkalić, Marina Ćendić Serafinović, Ratomir Jelić, Stefan Stojanović, Miroslav Sovrlić

E-ADRESS / Е-АДРЕСА: emina.mrkalic@pmf.kg.ac.rs, marina.cendic@pmf.kg.ac.rs, rjelic@uni.kg.ac.rs, sstojanovic1987@gmail.com, msovrlic@medf.kg.ac.rs

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DOI: 10.46793/ICCBI21.363M

ABSTRACT / САЖЕТАК:

Serum albumin is the major soluble protein in the circulatory system of humans. The metabolism of drugs, their distribution, free concentration, and efficacy depend on the drug-serum albumin interaction [1]. Accordingly, it is important to study the interactions of drugs with serum albumin, which determines the pharmacology and pharmacodynamics of drugs. Quercetin (QUE), a natural polyphenol widely distributed in many plant foods, such as fruits, vegetables, nuts, seeds, grains, and tea [2], bind to serum albumin  [3]. Tigecycline  (TGC), is a tetracycline  antibiotic widely used  in the treatment  of bacterial infections [4]. This study aimed to investigate the binding properties of TGC to HSA in the presence of QUE, under physiological conditions, by fluorescence spectroscopy.

KEY WORDS / КЉУЧНЕ РЕЧИ:

human serum albumin, interactions, tigecycline

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