STUDIES OF SUBSTITUTION REACTIONS WITH IMPORTANT BIOMOLECULES AND ANTIMICROBIAL ACTIVITY OF NOVEL ZN(II)-L-CU(II) COMPLEXES

1st International Conference on Chemo and BioInformatics, ICCBIKG  2021, (328-331)

AUTHOR(S) / АУТОР(И): Biljana Šmit, Asija Halilagić, Enisa Selimović, Jelena S. Katanić Stanković, Nikola Srećković, Tanja Soldatović

E-ADRESS / Е-АДРЕСА: biljana.smit@uni.kg.ac.rs, jkatanic@kg.ac.rs, tsoldatovic@np.ac.rs, eselimovic@np.ac.rs, asija.halilagic@gmail.com, nikola.sreckovic@pmf.kg.ac.rs

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DOI: 10.46793/ICCBI21.328S

ABSTRACT / САЖЕТАК:

New dinuclear Zn(II)-L-Cu(II) complexes with different bridging ligands were synthesized. Interactions of these complexes with biologically important nucleophiles, 5′-GMP, 5′-IMP and GSH, were investigated by Uv-Vis spectrofotometric method. The distances between the metal ions lead to less reactivity of both centers due to reduced electronic communication between them and an increasing of electron density on the metal centers itself. Both complexes showed moderate antimicrobial activity against most of the tested bacterial and fungal strains.

KEY WORDS / КЉУЧНЕ РЕЧИ:

heteronuclear complexes, Zn(II), Cu(II), biomolecules, bridging ligands, Uv-Vis spectroscopy

REFERENCES / ЛИТЕРАТУРА:

  • I. Bertini, H.B. Gray, E.I. Stiefel, J.S. Valentine, Biological inorganic chemistry. Structure and reactivity, University Science Books. Sausalito, CA (2007). b) E. Alessio, Bioinorganic Medicinal Chemistry, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim (2011).
  • S. Anbu, S. Kamalraj, B. Varghese, J. Muthumary, M. Kandaswamy, A Series of Oxyimine-Based Macrocyclic Dinuclear Zinc(II) Complexes Enhances Phosphate Ester Hydrolysis, DNA Binding, DNA Hydrolysis, and Lactate Dehydrogenase Inhibition and Induces Apoptosis, Inorg. Chem., 51 (2012) 5580-5592. b) T.V. Soldatović, E. Selimović, B. Šmit, D. Ašanin, N. Planojević, S. Marković, R. Puchta, B. Alzoubi, Interactions of zinc(II) complexes with 5′-GMP and their cytotoxic activity, J. Coord. Chem., 72 (2019) 690-706.
  • P.B. Stanić, M.V. Rodić, T.V. Soldatović, A.B. Pavić, N.S. Radaković, B.M. Šmit, M.D. Živković, Reaction of a 3-aryilidene-2-thiohydantoin derivative with polymeric trans-[CuCl2(DMSO)2]n complex: Unexpected isomerization to dinuclear cis-[{CuCl(DMSO)2}(μ-Cl)]2, J. Serb. Chem. Soc., 85 (2020) 1591-1603.
  • A. Hofmann, R. van Eldik, Thermodynamic and kinetic study of the interaction between the Pt(II) centres in [Pt2(N,N,N′,N′-tetrakis(2-pyridylmethyl)diamine)(H2O)2]4+. Influence of the bridging ligand, Dalton Trans., 15 (2003) 2979-2985. b) H. Ertürk, R. Puchta, R. van Eldik, Synthesis, characterization, thermodynamic and kinetic properties of a new series of dinuclear Pt(II) complexes, Eur, J. Inorg. Chem., 10 (2009) 1331-1338.