1st International Conference on Chemo and BioInformatics, ICCBIKG 2021, (68-71)
AUTHOR(S) / АУТОР(И): Miljan Milosevic, Nicola Di Trani, Vladimir Simic, Alessandro Grattoni, Milos Kojic
E-ADRESS / Е-АДРЕСА: firstname.lastname@example.org, email@example.com, firstname.lastname@example.org, email@example.com, firstname.lastname@example.org
ABSTRACT / САЖЕТАК:
In this work we present computational model for intraocular drug transport using coupled convective-diffusive equations. Model can simulate drug transport using either injection or by state of the art implant devices. We are using Navier-Stokes equation for fluid flow in vitreous humor, and composite smeared finite element (CSFE) for convection in rest of the eye and also for diffusion within the whole model. CSFE takes into account blood vessel properties, such as hydraulic and diffusive components. User interface tool CAD for pre- and post- processing is constructed which enables generation of geometries for patient specific purposes. Computational model provides results in a form convenient for investigation of effects of the drugs on different diseases, such as diabetic macular edema, uveitis, etc. This computational platform has potentials to become a powerful tool for optimization of therapies and simulation of different drugs.
KEY WORDS / КЉУЧНЕ РЕЧИ:
intraocular drug transport, computational model, finite element analysis, CSFE, Kojic Transport Model.
REFERENCES / ЛИТЕРАТУРА:
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- Di Trani, et .al, Nanofluidic microsystem for sustained intraocular delivery of therapeutics, Nanomedicine, 2019 Feb;16:1-9.
- J. Missel, Simulating Intravitreal Injections in Anatomically Accurate Models for Rabbit, Monkey, and Human Eyes, Pharm Res (2012) 29:3251–3272.
- Kojic, et al, A composite smeared finite element for mass transport in capillary systems and biological tissue, Comp. Meth. Appl. Mech. Engrg., 324 (2017) 413–437.
- Kojic, N. Filipovic, B. Stojanovic, N. Kojic, Computer Modelling in Bioengineering Theory, Examples and Software, J. Wiley and Sons, 2008.
- Kojic, et al. PAK-FE program for structural analysis, fluid mechanics, coupled problems and biomechanics. Bioengineering R&D Center for Bioengineering, Faculty of Engineering, Kragujevac, Serbia, www.bioirc.rs/index.php/software/5-pak (Accessed 30.08.2021).