MESOPOROUS SILICA AS A VEHICLE FOR ORGANOTIN(IV) COMPOUNDS

1st International Conference on Chemo and BioInformatics, ICCBIKG  2021, (60-63)

AUTHOR(S) / АУТОР(И): Goran N. Kaluđerović

E-ADRESS / Е-АДРЕСА: goran.kaluderovic@hs-merseburg.de

Download Full Pdf   

DOI: 10.46793/ICCBI21.060K

ABSTRACT / САЖЕТАК:

 

Free Ph3Sn(CH2)nOH (n = 3, 4, 6, 8 and 11) and immobilized organotin(IV) compounds, SBA- 15~Cl|Ph3Sn(CH2)nOH, were prepared and tested against different tumor cell lines. Both compounds and nanomaterials revealed strong cytotoxic potential. SBA-15~Cl|Ph3Sn(CH2)3OH as well as free compound induce caspase triggered apoptosis in human ovarian A2780 cells. Ph3Sn(CH2)6OH and corresponding nanomaterial induced apoptosis in mouse melanoma B16 cells. Survived clones of B16 cells demonstrated phenotypic changes, they differentiate toward melanocytes.

KEY WORDS / КЉУЧНЕ РЕЧИ:

cisplatin, organotin(IV) compounds, emodin, SBA-15, apoptosis, differentiation

REFERENCES / ЛИТЕРАТУРА:

  • N. Kaluđerović, R. Paschke, Anticancer metallotherapeutics in preclinical Development, Current Medicinal Chemistry 18 (2011) 4738-4752.
  • Ghosh, Cisplatin: The first metal based anticancer drug, Bioorganic Chemistry 88 (2019) 102925.
  • Ž. Knežević, G.N. Kaluđerović, Silicon-based nanotheranostics, Nanoscale 9 (2017), 12821- 12829.
  • Bensing, M. Mojić, S. Gómez-Ruiz, S. Carralero, D. Maksimović-Ivanić, S. Mijatović, G.N. Kaluđerović, Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph3Sn(CH2)3OH against A2780 ovarian carcinoma cell line, Dalton Transaction 45 (2016) 18984-18993.
  • Z. Bulatović, D. Maksimović-Ivanić, C. Bensing, S. Gómez-Ruiz, D. Steinborn, H. Schmidt, Mojić, A. Korać, I. Golić, D. Pérez-Quintanilla, M. Momčilović, S. Mijatović, G.N. Kaluđerović, Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment, Angewandte Chemie International Edition 53 (2014) 5982-5987.
  • Edeler, S. Arlt, V. Petković, G. Ludwig, D. Drača, D. Maksimović-Ivanić, S. Mijatović, G.N. Kaluđerović, Delivery of [Ru(η6-p-cymene)Cl2{Ph2P(CH2)3SPh-κP}] using unfunctionalized andmercapto functionalized SBA-15 mesoporous silica: Preparation, characterization and in vitro study, Journal of Inorganic Biochemistry 180 (2018) 155-162.
  • Krajnović, D. Maksimović-Ivanić, S. Mijatović, D. Drača, K. Wolf, D. Edeler, L.A. Wessjohann, G.N. Kaluđerović, Drug delivery system for emodin based on mesoporous silica SBA- 15, Nanomaterials 8 (2018) 322.
  • Edeler, D. Drača, V. Petković, F. Natalio, D. Maksimović-Ivanić, S. Mijatović, H. Schmidt, G.N. Kaluđerović, Impact of the mesoporous silica SBA-15 functionalization on the mode of action of Ph3Sn(CH2)6OH, Materials Science and Engineering C 100 (2019) 315-322.
  • Drača, D. Edeler, M. Saoud, B. Dojčinović, D. Dunđerović, G. Đmura, D. Maksimović-Ivanić,
  1. Mijatović, G.N. Kaluđerović, Antitumor potential of cisplatin loaded into SBA-15 mesoporous silica nanoparticles against B16F1 melanoma cells: in vitro and in vivo studies, Journal of Inorganic Biochemistry 217 (2021) 111383.
  • K. Hadjikakou, N. Hadjiliadis, Antiproliferative and anti-tumor activity of organotin compounds, Coordination Chemistry Reviews 253 (2009), 235–249.
  • Pérez-Quintanilla, S. Gómez-Ruiz, Ž. Žižak, I. Sierra, S. Prashar, I. Hierro, M. Fajardo, Z.D. Juranić, G.N. Kaluđerović, A new generation of anticancer drugs. Mesoporous materials modified with titanocene complexes, Chemistry A European Journal 22 (2009) 5588-5597.