ANTIRADIKALSKI KAPACITET (E)-N’-1-(2,4-DIOKSO-2H-HROMEN-3(4H)-ILIDENE)ETIL)-4-HIDROKSI-3-METOKSIBENZOHIDRAZIDA

Savetovanje o biotehnologiji sa međunarodnim učešćem (Čačak: 26 ; 2021) (str. 423-428)
 

АУТОР(И): Marko Antonijević, Dušica Simijonović, Ana Kesić, Edina Avdović, Zoran Marković

Е-АДРЕСА:

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DOI: 10.46793/SBT26.423A

САЖЕТАК:

Kumarini su široko rasprostranjena grupa jedinjenja. Poseduju širok spektar fizioloških dejstava, od antifungalnog, preko antikoagulativnog do antikancerogenog, pa su zbog toga pronašli primenu u lečenju različitih bolesti. U ovom radu ispitivana je sposobnost (E)-N‘-1-(2,4-diokso-2H-hromen-3(4H)-ilidene)etil)-4-hidroksi-3-metoksibenzohidrazida da inaktivira reaktivne kiseoni;ne vrste. Analiza dobijenih rezultata pokazala je da SET-PT (Single Electron Transfer Followed By Proton Transfer) mehanizam nije operativan. Sa druge strane, termodinamički parametri koji opisuju HAT (Hydrogen Atom Transfer) i prvi korak SPLET (Sequential Proton Loss-Electron Transfer) mehanizma ukazuju da će oba mehanizma biti operativni. Antiradikalski kapacitet ispitivanog jedinjenja sa radikalima opada u sledećem nizu: OH> OCH3> OC(CH3)3> OOH> OOCH3> OOCH2CH3.

КЉУЧНЕ РЕЧИ:

Antiradikalska aktivnost, DFT, Termodinamički pristup

ЛИТЕРАТУРА:

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