1st International Conference on Chemo and BioInformatics, ICCBIKG 2021, (297-299)
AUTHOR(S) / АУТОР(И): Marina D. Kostić, Vera M. Divac, Sven Mangelinckx
E-ADRESS / Е-АДРЕСА: marinak@uni.kg.ac.rs, vera.divac@pmf.kg.ac.rs, Sven.Mangelinckx@UGent.be
DOI: 10.46793/ICCBI21.297K
ABSTRACT / САЖЕТАК:
The discovery that palladium complexes possess a wide range of biological activities (from antitumor, -viral, -malarial, -fungal to antimicrobial activities) encourages further research in this scientific field. Herein we describe the synthesis and characterization of a novel palladium (II) complex, using [Pd(dien)Cl]Cl and 2-(azidomethyl)cyclopropane-1,1-dicarboxylic acid (azmcpda) as a ligand. [Pd(dien)Cl]Cl was selected as a starting material taking into consideration its importance as a model for the investigation of the substitution reactions in coordination chemistry and a deeper understanding of the biological activities of some structurally similar compounds. The ligand compound was synthesized by the procedure described in the literature. It is noteworthy to mention that 2- (azidomethyl)cyclopropane-1,1-dicarboxylic acid presents the precursor for the synthesis of 2- (aminomethyl)cyclopropane-1,1-dicarboxylic acid, as an example of the constrained γ-amino dicarboxylic acids. The synthesis was achieved by the conversion of the ligand compound into the corresponding sodium dicarboxylate salt and subsequent treatment with [Pd(dien)Cl]Cl (pH maintained between 6-7). The IR and NMR spectra, as well as elemental analysis have confirmed that the Na[Pd(dien)(azmcpda)]. H2O species was formed and that coordination of the ligand compound to the metal ion was established through carboxylate oxygen donor atom.
KEY WORDS / КЉУЧНЕ РЕЧИ:
palladium, cyclopropane, azide, dicarboxylic acid
REFERENCES / ЛИТЕРАТУРА:
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- S. Mangelinckx, M. Kostić, S. Backx, B. Petrović, N. De Kimpe., Synthesis of Racemic 2‐ (Aminomethyl)cyclopropane‐1,1‐dicarboxylic Acid as a New Constrained γ‐Amino Dicarboxylic Acid Bypassing Alkyl 3‐Aza‐2‐oxobicyclo[3.1.0]hexane‐1‐carboxylates, European Journal of Organic Chemistry, (2019) 5187-518